The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Further information concerning those agencies are founded on the following URLs: CNPq: jsessionid=7C28AB306E0BE450036DAE00943FFEB0, FAPERJ. All relevant data are within the paper.įunding: This study was supported by grants from the National Research Council (CNPq - 474116/2008-5) and the Research Supporting Agency of Rio de Janeiro State (FAPERJ - E-26/111.732/2011).

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that all data underlying the findings are fully available without restriction. Received: MaAccepted: JPublished: July 18, 2014Ĭopyright: © 2014 Boa et al. PLoS ONE 9(7):Įditor: Erik Svensjo, Universidade Federal do Rio de Janeiro (UFRJ), Brazil (2014) Chronic Aerobic Exercise Associated to Dietary Modification Improve Endothelial Function and eNOS Expression in High Fat Fed Hamsters. Our results indicate that an aerobic routine and/or dietary modification may cause significant improvements to high fat fed animals, diminishing visceral depots, increasing eNOS expression and reducing microcirculatory dysfunction.Ĭitation: Boa BCS, Souza MdGC, Leite RD, da Silva SV, Barja-Fidalgo TC, Kraemer-Aguiar LG, et al. Endothelial-independent microvascular reactivity was similar between groups, suggesting that only endothelial damage had occurred. Compared to HFSC and HFSCEX groups, HF and HFEX ones presented increased visceral fat impaired endothelial-dependent vasodilatation, macromolecular permeability increase after ischemia/reperfusion [(HF)40.5±4.2 (HFSC)*19.0☑.6 (HFEX)*18.6☒.1 and (HFSCEX)* 21.5☓.7 leaks/cm 2), decreased eNOS expression, increased leptin and glycaemic levels. Total body fat and aorta eNOS and iNOS expression by immunoblotting assay were evaluated on the experimental day. Microvascular reactivity in response to acetylcholine and sodium nitroprusside and macromolecular permeability increase induced by 30 minutes ischemia followed by reperfusion were assessed on the cheek pouch preparation. From week 12 to 20, animals were randomly separated in HF (no treatment change), return to standard chow (HFSC, n = 30), high fat chow associated to an aerobic exercise training program (AET) (HFEX, n = 30) and return to standard chow+AET (HFSCEX, n = 30). In this study we have investigated effects of exercise and/or dietary modification on microcirculatory function, body composition, serum glucose, iNOS and eNOS expression on 120 male hamsters treated for 12 weeks with high fat chow (HF, n = 30) starting on the 21 st day of birth.

Physical exercise has been used as non-pharmacological treatment to significantly reverse/attenuate obesity comorbidities. Obesity is epidemic in the western world and central adipose tissue deposition points to increased cardiovascular morbidity and mortality, independently of any association between obesity and other cardiovascular risk factors.

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